A study on knock out epsins 1 and 2 in mice showed embryonic death at day 10.
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Once the embryo is attached, infection from days 29 41 can result in embryonic infection and resultant embryonic death.
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It appears possible that either condition could cause embryonic death, or that both chromosomes could be responsible for sex selection.
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Knock out of the entire pathway results in early embryonic death, therefore most research of this nature utilised conditional knockouts of the pathway.
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Other results of Cripto disruption include the lack of posterior structures . and a block on the differentiation of cardiac myocyte, . both of which lead to embryonic death.
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For example, inactivation of Cripto during gastrulation disrupted the migration of newly formed mesenchymal mesoderm cells, resulting in the accumulation of cells around the primitive streak and eventual embryonic death.
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Mutations in " SMN2 " alone do not lead to disease, although mutations in both " SMN1 " and " SMN2 " result in embryonic death.
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The oil can also affect the eggs laid by affected females, often resulting in embryonic death or low birth weight . 5-20 microliters of oil can kill embryos if the egg comes into contact.
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